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Mediterranean Cruises from Southampton

Compare Mediterranean cruises departing from Southampton. Sail to the Mediterranean round-trip from Southampton with no flights to catch — just drive to the port and board. Browse live Mediterranean sailings from Southampton across all major cruise lines, with prices, dates and what is bundled into each fare.

Prices checked 0m ago34 sailings matching
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Compare mediterranean cruises from southampton

Prices are per person based on two sharing the lowest available cabin grade, refreshed continuously from every major line.

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MSC Virtuosa — 7-night France & Iberian Shores7 NIGHTS
MSC Cruises · MSC Virtuosa

7-night France & Iberian Shores

Mediterranean · Southampton
From
£560pp
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MSC Virtuosa — France and Spain cruise from SouthamptonSave 13%7 NIGHTS
MSC Cruises · MSC Virtuosa

France and Spain cruise from Southampton

Mediterranean · Southampton
From
£569pp£656
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MSC Virtuosa — 9-night Atlantic Shores to the Med & 2-night Barcelona11 NIGHTS
MSC Cruises · MSC Virtuosa

9-night Atlantic Shores to the Med & 2-night Barcelona

Mediterranean · Southampton
Flights
From
£599pp
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Queen Elizabeth — Spain and France7 NIGHTS
Cunard · Queen Elizabeth

Spain and France

Mediterranean · Southampton
From
£621pp
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Queen Victoria — 7-night Spain And Portugal fr Southampton7 NIGHTS
Cunard · Queen Victoria

7-night Spain And Portugal fr Southampton

Mediterranean · Southampton
From
£630pp
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Queen Mary 2 — 7-night Portugal & Spain fr Southampton7 NIGHTS
Cunard · Queen Mary 2

7-night Portugal & Spain fr Southampton

Mediterranean · Southampton
From
£678pp
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Queen Anne — Spain and France7 NIGHTS
Cunard · Queen Anne

Spain and France

Mediterranean · Southampton
From
£678pp
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MSC Virtuosa — 7-night All Inclusive Spanish Shores & French Rivieras7 NIGHTS
MSC Cruises · MSC Virtuosa

7-night All Inclusive Spanish Shores & French Rivieras

Mediterranean · Southampton
Drinks
From
£679pp
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Queen Anne — 7-night Spain and France in Luxury7 NIGHTS
Cunard · Queen Anne

7-night Spain and France in Luxury

Mediterranean · Southampton
From
£698pp
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Sky Princess — 7-Day Spain & FranceSave 4%7 NIGHTS
Princess Cruises · Sky Princess

7-Day Spain & France

La Coruña · Bilbao · Le Verdon-sur-Mer
From
£713pp£739
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MSC Virtuosa — 10 Night Western MediterraneanSave 8%10 NIGHTS
MSC Cruises · MSC Virtuosa

10 Night Western Mediterranean

Barcelona · Marseille · Genoa
Wi-Fi
From
£831pp£899
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Freedom of the Seas — Spanish Flair cruise from SouthamptonSave 3%9 NIGHTS
Royal Caribbean · Freedom of the Seas

Spanish Flair cruise from Southampton

Southampton · Vigo · Lisbon
From
£862pp£886
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MSC Meraviglia — France, Portugal, Morocco & Spain from Southampton9 NIGHTS
MSC Cruises · MSC Meraviglia

France, Portugal, Morocco & Spain from Southampton

Southampton · Brest · Lisbon
From
£872pp
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MSC Virtuosa — 10 Night Western Mediterranean10 NIGHTS
MSC Cruises · MSC Virtuosa

10 Night Western Mediterranean

Barcelona · Marseille · Genoa
Flights Wi-Fi
From
£890pp
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Arvia — Spain & FranceSave 2%13 NIGHTS
P&O Cruises · Arvia

Spain & France

Mediterranean · Southampton
From
£980pp£999
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Borealis — Regions of Northern SpainSave 2%7 NIGHTS
Fred. Olsen Cruise Lines · Borealis

Regions of Northern Spain

Southampton · Santander · Getxo
Drinks
From
£1,077pp£1,099
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Celebrity Apex — 11 Night Italy & Greek Islands11 NIGHTS
Celebrity Cruises · Celebrity Apex

11 Night Italy & Greek Islands

Naples · Santorini · Athens
Flights Wi-Fi
From
£1,110pp
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MSC Virtuosa — 14-night Mediterranean Adventure14 NIGHTS
MSC Cruises · MSC Virtuosa

14-night Mediterranean Adventure

Mediterranean · Southampton
From
£1,114pp
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MSC Virtuosa — Western MedSave 8%14 NIGHTS
MSC Cruises · MSC Virtuosa

Western Med

Southampton · Lisbon · Cádiz
From
£1,192pp£1,289
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Aurora — Spain Portugal and MoroccoSave 3%14 NIGHTS
P&O Cruises · Aurora

Spain Portugal and Morocco

Southampton · Funchal · Agadir
From
£1,230pp£1,269
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Anthem of the Seas — 14 Night Eastern Mediterranean14 NIGHTS
Royal Caribbean · Anthem of the Seas

14 Night Eastern Mediterranean

Rome · Santorini · Mykonos
Flights Drinks Wi-Fi
From
£1,330pp
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MSC Virtuosa — Portugal and Spain cruise from Southampton9 NIGHTS
MSC Cruises · MSC Virtuosa

Portugal and Spain cruise from Southampton

Mediterranean · Southampton
Drinks
From
£1,363pp
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Sky Princess — Mediterranean Adventurer cruise from Southampton14 NIGHTS
Princess Cruises · Sky Princess

Mediterranean Adventurer cruise from Southampton

Southampton · Seville (Cadiz) · Barcelona
From
£1,383pp
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Sky Princess — Mediterranean Adventurer cruise from Southampton14 NIGHTS
Princess Cruises · Sky Princess

Mediterranean Adventurer cruise from Southampton

Southampton · Seville (Cadiz) · Barcelona
From
£1,403pp
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  About This Search

Why book mediterranean cruises from southampton?

Compare Mediterranean cruises departing from Southampton. Sail to the Mediterranean round-trip from Southampton with no flights to catch — just drive to the port and board. Browse live Mediterranean sailings from Southampton across all major cruise lines, with prices, dates and what is bundled into each fare.

Rather than checking each cruise line one at a time, we pull mediterranean cruises from southampton from every major operator into a single comparison. That means you see the real lowest price for each sailing — including what is bundled into the fare, such as flights, drinks packages and Wi-Fi — so you can compare like for like before you book. Every listing links straight through to the full itinerary, cabin grades and departure details.

Cruise prices move with demand, so the best fares tend to go to early bookers and to those who stay flexible on dates. Use the filters on our main cruise search to widen or narrow these results by price, cruise line or month, and set up a price alert if you would rather wait for a drop.